Late Show with David Letterman (Season 22)

Luke Wilson, Julie Chen, Lee Brice (Episode 1)

Air date: 2014-09-02

Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers (Episode 2)

Air date: 2014-09-03

Steve Buscemi, Indy Car Season Champ, Alt-J (Episode 3)

Air date: 2014-09-04

Tina Fey, Moody McCarthy, Kevin Drew (Episode 4)

Air date: 2014-09-05

Bill Maher, Henrik Lundqvist, Spoon (Episode 5)

Air date: 2014-09-08

Michael Strahan, Richard Branson, Interpol (Episode 6)

Air date: 2014-09-09

Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson (Episode 7)

Air date: 2014-09-10

Jason Bateman, Billy Eichner, Ryan Adams (Episode 8)

Air date: 2014-09-11

Mindy Kaling, Jake Johannsen, Maddie & Tae (Episode 9)

Air date: 2014-09-12

Mark Harmon, "Jungle" Jack Hanna (Episode 10)

Air date: 2014-09-22

Denzel Washington, Lenny Kravitz (Episode 11)

Air date: 2014-09-23

Kelly Ripa, Jim Gaffigan, Paloma Faith (Episode 12)

Air date: 2014-09-24

Jerry Seinfeld, Michael Jackson ONE (Episode 13)

Air date: 2014-09-25

Ted Danson, Andrew Norelli (Episode 14)

Air date: 2014-09-26

Neil Patrick Harris, Jamie Oliver, Aretha Franklin (Episode 15)

Air date: 2014-09-29

John Oliver, Maggie Q, Bleachers (Episode 16)

Air date: 2014-09-30

Bill O'Reilly, Cristin Milioti (Episode 17)

Air date: 2014-10-01

Johnny Galecki, Andre Benjamin, Delta Spirit (Episode 18)

Air date: 2014-10-02

Mariska Hargitay, Simon Amstell, Kandace Springs (Episode 19)

Air date: 2014-10-03

Aziz Ansari, Tom Dreesen (Episode 20)

Air date: 2014-10-06

Robert Downey Jr., Sarah Paulson, Lizzo (Episode 21)

Air date: 2014-10-07

Anderson Cooper, Gina Rodriguez, Hatsune Miku (Episode 22)

Air date: 2014-10-08

Robert Duvall, Elle Fanning, Rival Sons (Episode 23)

Air date: 2014-10-09

Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley (Episode 24)

Air date: 2014-10-10

Overview: TV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.

Russell Brand, Dave Grohl, Foo Fighters (Episode 25)

Air date: 2014-10-13

Michael Keaton, Foo Fighters (Episode 26)

Air date: 2014-10-14

Bill Murray, Foo Fighters (Episode 27)

Air date: 2014-10-15

Tom Selleck, Jenny Slate, Foo Fighters (Episode 28)

Air date: 2014-10-16

Jessica Chastain, Lenny Marcus, Foo Fighters (Episode 29)

Air date: 2014-10-17

Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis (Episode 30)

Air date: 2014-10-27

Taylor Swift, Tom Mison (Episode 31)

Air date: 2014-10-28

Jim Carrey, David Tennant (Episode 32)

Air date: 2014-10-29

Brian Williams, Perfume Genius (Episode 33)

Air date: 2014-10-30

Keith Olbermann, Brian Regan, Run the Jewels (Episode 34)

Air date: 2014-10-31

Martin Short, Father John Misty (Episode 35)

Air date: 2014-11-03

Jennifer Lopez, Rob Riggle, Kimbra (Episode 36)

Air date: 2014-11-05

Whoopi Goldberg, Jimmy Page, Mapei (Episode 37)

Air date: 2014-11-06

Amy Schumer, Jeff Caldwell (Episode 38)

Air date: 2014-11-07

Katie Holmes, Alex Zanardi (Episode 39)

Air date: 2014-11-10

Steve Carell, Martha Stewart, OK Go (Episode 40)

Air date: 2014-11-11

Jennifer Lawrence, Boris Johnson (Episode 41)

Air date: 2014-11-12

Jon Stewart, Shawn Mendes (Episode 42)

Air date: 2014-11-13

Kristin Chenoweth; Chris Young (Episode 43)

Air date: 2014-11-14

Overview: Actress Kristin Chenoweth; Chris Young performs.

Jason Sudeikis, Allison Janney, Damien Rice (Episode 44)

Air date: 2014-11-17

Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger (Episode 45)

Air date: 2014-11-18

Regis Philbin, Hundred Waters (Episode 46)

Air date: 2014-11-19

Edward Norton, Jessye Norman (Episode 47)

Air date: 2014-11-20

Norman Lear, TV on the Radio (Episode 48)

Air date: 2014-11-21

Seth Rogen, Amy Sedaris (Episode 49)

Air date: 2014-11-24

Emily Blunt, Adam Resnick, Wu-Tang Clan (Episode 50)

Air date: 2014-11-25

Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz (Episode 51)

Air date: 2014-11-26

Joaquin Phoenix, Cristela Alonzo, Al Green (Episode 52)

Air date: 2014-12-08

Ben Stiller, Olivia Munn, LaLa Brooks (Episode 53)

Air date: 2014-12-09

Meryl Streep, Rebel Wilson, J. Cole (Episode 54)

Air date: 2014-12-10

Chris Rock, Sting (Episode 55)

Air date: 2014-12-11

Jamie Foxx, Robert Klein, Dan Penn (Episode 56)

Air date: 2014-12-12

Emma Stone Top, Marcus Mariota, Bob Seger (Episode 57)

Air date: 2014-12-15

New Holiday Toys, Anna Kendrick, Charli XCX (Episode 58)

Air date: 2014-12-16

Tom Brokaw, Will Nelson & Billy Joe Shaver (Episode 59)

Air date: 2014-12-17

Rosie O’Donnel,l Jeff Altman (Episode 60)

Air date: 2014-12-18

Jay Thomas, Josh Brolin, Darlene Love (Episode 61)

Air date: 2014-12-19

Overview: The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).

Kathy Griffin, David Oyelowo, Lera Lynn (Episode 62)

Air date: 2015-01-05

Ethan Hawke, Allison Williams, Parquet Courts (Episode 63)

Air date: 2015-01-06

Julianne Moore, Catfish & the Bottlemen (Episode 64)

Air date: 2015-01-07

Donald Trump, Chelsea Peretti, Foxygen (Episode 65)

Air date: 2015-01-08

Michael Somerville, Nicole Atkins (Episode 66)

Air date: 2015-01-09

Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones (Episode 67)

Air date: 2015-01-12

Anderson Cooper, Shovels & Rope (Episode 68)

Air date: 2015-01-13

Amanda Peet, Ryn Weaver (Episode 69)

Air date: 2015-01-14

Larry David, Dan Patrick, Sleater-Kinney (Episode 70)

Air date: 2015-01-15

Urban Meyer, Johnny Beehner, Ella Henderson (Episode 71)

Air date: 2015-01-16

Louis CK, Nicolle Wallace, the Lone Bellow (Episode 72)

Air date: 2015-01-26

Andrew Luck, Oscar Isaac, Drenge (Episode 73)

Air date: 2015-01-27

Viola Davis, Ben Schwartz, Marty Stuart (Episode 74)

Air date: 2015-01-28

John Oliver, Mayim Bialik, Death Cab for Cutie (Episode 75)

Air date: 2015-01-29

Aziz Ansari, Brian Kiley, Ben Howard (Episode 76)

Air date: 2015-01-30

Jack Hanna, Sharon Jones and the Dap-Kings (Episode 77)

Air date: 2015-02-02

Dr. Phil McGraw, Robin Tunney, Diana Krall (Episode 78)

Air date: 2015-02-03

Ryan Reynolds, Dierks Bentley (Episode 79)

Air date: 2015-02-04

Martin Short, Bettye Lavette (Episode 80)

Air date: 2015-02-05

Sienna Miller, Andy Kindler, Bob Mould (Episode 81)

Air date: 2015-02-06

Steve Carell, Dr. Cornel West (Episode 82)

Air date: 2015-02-09

Courtney Love, Chris Elliott, Rhiannon Giddens (Episode 83)

Air date: 2015-02-10

Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear (Episode 84)

Air date: 2015-02-11

Tom Hanks, Sturgill Simpson (Episode 85)

Air date: 2015-02-12

Bill Hader, Pat McGann, Shakey Graves (Episode 86)

Air date: 2015-02-13

Matthew Perry, Adam Scott, Kishi Bashi (Episode 87)

Air date: 2015-02-16

Dakota Johnson, David Tochinskiy, Twin Shadow (Episode 88)

Air date: 2015-02-17

Will Smith, Grizfolk (Episode 89)

Air date: 2015-02-18

Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko (Episode 90)

Air date: 2015-02-19

Kid Scientists, Sean Hayes, Judah & the Lion (Episode 91)

Air date: 2015-02-20

Helen Mirren, the 2015 Daytona 500 winner, Steve Earle (Episode 92)

Air date: 2015-02-23

Matthew Broderick, Ellie Kemper, JD McPherson (Episode 93)

Air date: 2015-02-24

Julianna Margulies, Eric Ripert, Glass Animals (Episode 94)

Air date: 2015-02-25

Kevin Spacey, Lily James, Alabama Shakes (Episode 95)

Air date: 2015-03-09

Patricia Arquette, Will Butler (Episode 96)

Air date: 2015-03-10

Kelsey Grammer, Stevie Wonder (Episode 97)

Air date: 2015-03-11

Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew (Episode 98)

Air date: 2015-03-12

Kevin Bacon, Jimmie Walker, Airborne Toxic Event (Episode 99)

Air date: 2015-03-13

Shailene Woodley, Dr. Cornel West, Matthew E. White (Episode 100)

Air date: 2015-03-16

Will Ferrell, Glen Hansard (Episode 101)

Air date: 2015-03-17

Norm MacDonald, Theo James (Episode 102)

Air date: 2015-03-18

Ben Stiller, Tove Lo (Episode 103)

Air date: 2015-03-23

Bill O'Reilly, Aubrey Plaza (Episode 104)

Air date: 2015-03-24

James Franco, Jake Johannsen, Action Bronson (Episode 105)

Air date: 2015-03-25

Neil Patrick Harris, Charlie Cox, the Suffers (Episode 106)

Air date: 2015-03-30

David Duchovny, Josh Gad, Houndmouth (Episode 107)

Air date: 2015-03-31

Sen. Al Franken, Billy Eichner, David Sanborn (Episode 108)

Air date: 2015-04-01

Kelly Ripa, Aasif Mandvi, Fat White Family (Episode 109)

Air date: 2015-04-02

Mike Myers, Nick Griffin, Banks (Episode 110)

Air date: 2015-04-03

Sarah Jessica Parker, Julie Chen, Asleep at the Wheel (Episode 111)

Air date: 2015-04-13

Billy Crystal, Chris Russo, Chris Stapleton (Episode 112)

Air date: 2015-04-14

Michael J. Fox, Iron & Wine, Ben Bridwell (Episode 113)

Air date: 2015-04-15

Kevin James, Tom Dreesen, Tracy Chapman (Episode 114)

Air date: 2015-04-16

Alec Baldwin, John Mayer (Episode 115)

Air date: 2015-04-17

John Travolta, Amy Schumer, the Waterboys (Episode 116)

Air date: 2015-04-20

Piedmont Bird Callers, Paul Rudd (Episode 117)

Air date: 2015-04-21

Bruce Willis, Dawes (Episode 118)

Air date: 2015-04-22

Robert Downey Jr., Chris Russo, Elvis Costello (Episode 119)

Air date: 2015-04-23

Jerry Seinfeld, Jason Isbell & Amanda Shires (Episode 120)

Air date: 2015-04-24

Scarlett Johansson, John Mellencamp, Todd Rundgren (Episode 121)

Air date: 2015-04-27

Michael Keaton, Future Islands (Episode 122)

Air date: 2015-04-28

Jack Hanna, John Popper (Episode 123)

Air date: 2015-04-29

First Lady Michelle Obama Hootie and the Blowfish (Episode 124)

Air date: 2015-04-30

Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor (Episode 125)

Air date: 2015-05-01

President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile (Episode 126)

Air date: 2015-05-04

Reese Witherspoon, Nathan Lane, Mumford & Sons (Episode 127)

Air date: 2015-05-05

Martin Short, Norah Jones (Episode 128)

Air date: 2015-05-06

Tina Fey, First Aid Kit (Episode 129)

Air date: 2015-05-07

Ray Romano, Brian Regan, Dave Matthews Band (Episode 130)

Air date: 2015-05-08

Howard Stern, Don Rickles (Episode 131)

Air date: 2015-05-11

Bill Clinton, Adam Sandler (Episode 132)

Air date: 2015-05-12

Julia Roberts, Paul Shaffer, Ryan Adams (Episode 133)

Air date: 2015-05-13

Al Pacino, George Clooney, Tom Waits (Episode 134)

Air date: 2015-05-14

Oprah Winfrey, Norm Macdonald (Episode 135)

Air date: 2015-05-15

Tom Hanks, Eddie Vedder (Episode 136) 6.0

Air date: 2015-05-18

Bill Murray, Bob Dylan (Episode 137)

Air date: 2015-05-19

The Final Late Show with David Letterman (Episode 138) 6.0

Air date: 2015-05-20

Overview: 6,028th broadcast

Episode 149 (Episode 139)

Air date: 2015-05-20

Overview: The final episode includes surprises, memorable highlights and the last Top Ten List.