A year after the death of his friend and partner Sherlock Holmes at the hands of Moriarty, Dr. John Watson resumes his medical career as the head of a clinic dedicated to treating rare disorders. However, he soon finds that his old life is not done with him yet.
Writer: Craig Sweeny
Air date: 2025-10-13
Runtime: 43 min
Overview: Watson and the fellows spring back into action when Mary’s mother accidentally poisons herself while suffering from a rare form of dementia that is progressing with impossible speed. Meanwhile, Sherlock Holmes resurfaces after being presumed dead.
Writer: Michael Narducci
Air date: 2025-10-20
Runtime: 43 min
Overview: A microbiology researcher returns from an expedition to Siberia, leading to a possible outbreak of a revived pathogen. Watson reconnects with Sherlock Holmes.
Writer: Elizabeth J.B. Klaviter
Air date: 2025-10-27
Runtime: 43 min
Overview: Watson and the team work alongside Laila to help a patient named Maxine, a 30-year-old who looks 10 years old.
Writer: Charly Evon Simpson
Air date: 2025-11-03
Runtime: 43 min
Overview: Watson and the team jump into action when four new patients are brought to UHOP with wounds that appear to be infected with a flesh-eating bacterium following a tornado. Meanwhile, Shinwell searches for meaning as a nursing student and Adam’s wedding to Lauren risks being halted.
Writer: Craig Sweeny
Air date: 2025-11-10
Runtime: 43 min
Overview: While visiting another hospital, Watson becomes convinced that a coma patient is suffering from locked-in syndrome and has been mistaken for a coma patient for over a decade. After the patient is transferred to UHOP for treatment, he shocks the team with chilling messages. Meanwhile, Sherlock is back in town and is staying with Watson.
Writer: Anna Mackey
Air date: 2025-11-17
Runtime: 43 min
Overview: Watson and the fellows race against time to save the life of Xavier, a 21-year-old athlete with a fast-growing, seemingly incurable cancer. Meanwhile, Mycroft Holmes lets Watson know his team’s work at UHOP may no longer have funding available.
Writer: Teresa Tuan
Air date: 2025-11-24
Runtime: 43 min
Overview: Watson's father, Hamish, visits UHOP to introduce Watson and the fellows to his protégé, Annabelle, a saxophone prodigy with musically induced blackouts. As Annabelle's condition worsens, Watson must confront his long-standing tensions with his father in order to save her.
Writer: Charly Evon Simpson
Air date: 2025-12-01
Runtime: 43 min
Overview: UHOP veers into terror when Watson and the fellows are taken hostage by a man with a bomb strapped to his chest who is desperate to find a cure for his 9-year-old daughter’s illness.
Writer: Craig Sweeny
Air date: 2025-12-08
Runtime: 43 min
Overview: Watson and the fellows help Laila’s son Micah – who was injured in a car accident while pursuing his crush, Bex, with the help of his AI chatbot.
Writer: Adam Samuel Goldman
Air date: 2025-12-15
Runtime: 43 min
Overview: Watson’s biohacker friend Hobie returns when he rushes his new girlfriend to the Holmes Clinic after they partake in a gene-editing experiment that goes wrong. Meanwhile, Watson becomes suspicious of Sherlock.
Writer: Jason Inman
Air date: 2026-03-01
Runtime: 43 min
Overview: Watson and the fellows race against the clock to save a man and his pregnant wife from a terrifying sinkhole. Meanwhile, Ingrid’s future with her therapy group becomes unclear.
Writer: Anna Mackey
Air date: 2026-03-08
Runtime: 43 min
Overview: When a patient arrives at the Holmes Clinic plagued by a mysterious neurological disorder, Watson and the fellows discover they were forced to eat their parents amid a childhood survival incident. Meanwhile, Adam is struggling with how his future will change as a father.
Writer: Bashir Gavriel
Air date: 2026-03-15
Runtime: 43 min
Overview: Watson and the fellows fight to revive a 30-year-old woman, Audrey, after her heart inexplicably stops repeatedly until they discover she has a rare phenomenon called Lazarus syndrome. As these revivals continue, she uses the short window of time available to right her greatest wrong.
Writer: Charly Evon Simpson
Air date: 2026-03-22
Runtime: 43 min
Overview: Watson is sued for Wrongful Life by a long-term patient suffering from VACTERL association, after undergoing multiple painful surgeries.
Writer: Charly Evon Simpson
Air date: 2026-03-29
Runtime: 43 min
Overview: Watson and the fellows race to save the life of a young woman who needs a lifesaving kidney donation. Meanwhile, Sherlock returns to help crack unsolved cases in Pittsburgh.
Writer: Shardé Miller
Air date: 2026-04-05
Runtime: 43 min
Overview: Watson investigates a case involving a mentally unstable mother, with the woman's delusions serving as a mirror to his own newly discovered hallucinations.
Writer: Adam Pasen
Air date: 2026-04-12
Runtime: 43 min
Overview: In the wake of the car accident, Watson and Laila lie injured and awaiting rescue as the team races to find them before it’s too late. Meanwhile, in a state between life and death, Watson’s mind plays out a modern-day investigation of a case that has long haunted him.
Writer: Michael Narducci
Air date: 2026-04-19
Runtime: 43 min
Overview: Following his brain tumor diagnosis, Watson goes on medical leave to seek treatment, leaving Mary in charge of The Holmes Clinic as a notorious South American dictator demands Watson see to his mysterious autoimmune condition personally. Meanwhile, Ingrid grows more concerned about Beck’s obsession with Sasha.
Writer: Teresa Tuan
Air date: 2026-04-26
Runtime: 43 min
Overview: As Adam's wife goes in for a C-section to deliver triplets, chaos ensues when their OB-GYN passes out in the operating room. Meanwhile, a severe storm detours Watson and Mary's trip to find a renowned doctor to remove Watson's brain tumor.
Writer: Sharon Moalem
Air date: 2026-05-03
Runtime: 44 min
Overview: A seemingly random murder outside of UHOP sets the stage for the arrival of someone from Watson and Sherlock Holmes' past.
